Regisseur Francis Lawrence ("Constantine") erzählte bei einem Interview zu seinem neuen Film "I Am Legend", dass er durchaus Lust auf einen zweiten Teil zu "Constantine" habe. Alles hinge nur davon ab, ein geeignetes Drehbuch zu finden. Auch könnte er sich vorstellen, ein Prequel statt eines Sequels zu drehen, ist sich aber noch alles andere als sicher:

"I like origin stories, that would be cool. What worked for me is the film came from the 'Dangerous Habits' storyline - he had cancer and he was dying. To me that was the core of the story. It's why the movie works for me, because the story couldn't be more personal. People have thrown concepts around [for a sequel] and I go 'Why does he give a f**k?' In the first film he's trying to save his own skin. Everything else, you can come up with these stories where he goes to different lands and fight the bad guys or witch doctors, but I think it all falls flat. Until someone comes up with a great idea, whether it's earlier or later, we'll just have to see."